ReBorn – Non-invasive lipolysis using innovative Led Technology


Non-surgical fat reduction procedures are one of the fastest growing categories in the aesthetics market, with constantly growing demand year over year. Two of the leading and most popular treatment technologies on the market are cryolipolysis and heat-induced lipolysis, both triggering adipose cell apoptosis, resulting in permanent fat reduction. Both technologies achieve a similar aesthetic result over a similar time period, powered by two different technological approaches that achieve fat cell apoptosis in completely opposite ways. Cryolipolysis, or “fat freezing”, uses non-invasive cooling of body fat while light/thermal-based technologies elevate the targeted adipose cells in order to achieve apoptosis.


Light-based non-invasive lipolysis has been gaining significant traction and popularity over the past several years, with a rapid increase in both the number of installed devices and the number of patient treatments being administered. This hyperthermic treatment increases adipose tissue temperature to 42-47oC for a sustained period of time, induces adipocyte injury and elicits an inflammatory response. The increase in temperature needed to achieve this target temperature over normal body temperature is relatively minimal – less than 100C. For comparison, the temperature needed in order to achieve effective cryolipolysis is -110C, a significant difference of ~450C over normal body temperature.



As mentioned, the goal of light-based treatment for non-invasive lipolysis is to produce fat cell apoptosis by elevating the cell temperature to 42-47oC for an extended amount of time (~25m). This is achieved by delivering photons to the predefined fat layer in the body  at a wavelength which is absorbed by the fat cells. The absorption in the fat cells is limited to a depth of several mm, in order to prevent penetration of light into deeper tissues. Upon reaching the fat cells, the absorbed light converts to heat and the deeper fat layer is subsequently heated up by conduction of heat (thermal conduction). The thermal conductivity is not dependent on the wavelength; it is a function of thermal tissue properties only.


The emitted light passes the epidermis and dermis layers of the skin on its way to the target fat cells, and is partially absorbed in these layers. This can lead to an increase in skin temperature, which is offset by external, active, contact cooling during the light-based treatment of the area.


The amount of thermal tissue damage can be quantified from the relationship between exposure time and tissue temperature. At a moderate increase in temperature to 6oC above normal (i.e., 43oC), the structural integrity of the lipid bilayer is lost, and at a temperature of 45oC for more than 5 minutes, cell membranes show damage. The injured adipocytes are removed naturally over time by the body’s lymphatic system through body inflammatory process.


A variety of energy sources can potentially be used to produce such heating, including ultrasound, radiofrequency (RF) or a 1060 nm diode laser. The diode laser technology is perhaps the most prevalent and widespread technology among the thermal treatment technologies. Radiation at 1060nm wavelength heats the fat layer with controlled temperature elevation, distributing the heating more evenly over a broad zone conspired to higher wavelengths. Studies of hyperthermia induced tissue damage and ex-vivo temperature measurements have shown that hyperthermic temperature can be achieved and maintained in subcutaneous adipose tissue by a 1060 nm lased in conjunction with surface cooling.


The laser light is administered to the target treatment area using applicators that are affixed to the treated area during the treatment period. The focused laser beam is dispersed in the applicator, creating a treatment spot size of ~4x6cm (current leading laser device spot size).



Recent advancements in technology and engineering have seen the introduction of a new light source for non-invasive lipolysis – Power LED (Light Emitting Diode) technology. ReBorn by Lightfective, a pioneer in the use of Power LED technology for aesthetic treatments, us es patented Power LED technology in the 940nm wavelength range to optimize thermal lipolysis. While LED technology has been around for decades and is used in a broad variety of applications in various fields, previous attempts to harness this technology for light-based medical and aesthetic treatments have yielded limited results until recently due to insufficient power. The old generation of LEDs emit light in the mW range, while the newer military and medical-grade Power LEDs offer better electrical-to-light efficiency and reach intensities hundreds of times greater, generating infrared radiation in the full W range.


Light absorption in fat is very similar for both 940nm and 1060nm wavelengths, with slightly increased absorption for 940 mm as seen in the chart below. This translates to a to a safer treatment profile for the 940nm as the absorption in fat is confined within a few mm in depth, thus preventing the light from penetrating into deeper tissues.


After the initial light absorption in the fat, the heat is delivered to deeper fat layers by thermal conduction. Thermal conduction is dependent on thermal tissue properties and is not dependent on wavelength. Therefore, the thermal conduction effect is equivalent for both light sources.

Light absorption in the epidermis and dermis layers is higher in 940nm than it is in 1060nm. This is compensated by actively cooling the skin and maintaining a predefined temperature on the skin surface.

Like laser-based and other thermal non-invasive lipolysis devices, ReBorn’s LED technology delivers the required light energy using a set of applicators. The use of LED technology enables the creation of an efficient array of LEDs, resulting in uniform heat dispersion at lower, safer levels and a larger spot size of 5X7cm – 45% larger than the laser spot size.

The typical diode laser provides focused heat by diffusing light from a single source over the treatment area – leading to a heating difference of up to 60% between the applicator’s center and periphery. In order to distribute the light homogenously on a large treatment area, the laser requires additional optical element(s) to disperse the light beam.

In contrast, ReBorn’s proprietary Power LED design has a semi-wide (80°) optical angle and uses multiple light sources (precision array of 63 LEDs). By distributing energy far more homogeneously, this produces greater clinical efficacy and consistency over the entire treatment area, as seen in the following diagram:



The characteristics and properties of the ReBorn 940nm LED device provide enhanced safety and efficacy vs. the 1060nm laser diode systems. Safety is enhanced because the LED device provides a more homogeneous light (and heat) distribution over treatment area, using multiple and dispersed light sources. In addition, the 940nm wavelength has higher absorption in fat, thus preventing the light from penetrating into deeper tissues. Furthermore, the LED provides a more divergent light source, which is less dangerous for unprotected eyes.


LED devices have enhanced efficacy over laser diode devices. Both devices emit similar light energy (up to 1.4W/cm2) and have similar absorption in fat, and as the thermal conduction is identical, the temperature profile in the fat tissues is similar. However, the LED’s superior homogenous light distribution and the significantly larger spot size enables treating a larger treatment area per treatment, with more unform results across the entire accumulated treatment area. Based on the properties and parameters of the different light sources, it appears that the LED at 940nm can use less power to achieve the same temperature gradient with more comfort to the patient.


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